5/20/2023 0 Comments AdrenocorticalHospital stay was shorter for laparoscopic surgery than open surgery (mean difference - 2.49 days, 95% CI - 2.95 to - 2.04 I 2 = 45%). Additionally, open surgery had more favorable overall survival (OR 0.56, 95% CI 0.44-0.72 I 2 = 0%) and recurrence-free rates (OR 0.60, 95% CI 0.42-0.85 I 2 = 38%) than laparoscopic surgery at 3 years. Open surgery demonstrated a lower rate of positive resection margin compared with laparoscopic surgery (odds ratio 1.52, 95% confidence interval 1.10-2.10 I 2 = 0%). The review was registered prospectively on the PROSPERO database (CRD42022316050).įrom 183 studies screened, 11 studies met the eligibility criteria, with a total of 1617 patients with adrenocortical carcinoma undergoing either laparoscopic surgery (n = 472) or open surgery (n = 1145). The Cochrane, Embase, PubMed, Scopus, and Web of Science databases were searched for articles from inception to May 2022, by two independent reviewers using the preferred reporting items for systematic reviews and meta-analysis (PRISMA) guidelines. This study aims to evaluate the safety and efficacy of laparoscopic surgery and open surgery in the management of adrenocortical carcinoma. Laparoscopic surgery is considered a standard treatment for benign adrenal tumors however, no consensus has been reached on the optimal resection technique for adrenocortical carcinomas.
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